MCAS (mast cell activation syndrome, mast cell disorder) is a condition characterized by increased mast cell activation or infiltration of mast cells into organs creating a hyper-sensitized, overly robust immune response. We want the body to respond to foreign invaders- think viruses, bacteria, environmental insults and other pathogens- but we do not want the immune response to become so sensitive and overactive it mounts a strong response to everyday exposures (foods, odors, cosmetics, clothing).

There are 3 types of MCAS, primary, secondary and idiopathic. MCAS can vary in severity and organ involvement. MCAS is most commonly secondary to an allergic or chronic inflammatory response or disorder. Systemic mastocytosis is rare and can be genetic or due to changes in bone marrow or mast cell progenitors.

At Aspen Integrative Medical Center, Dr. Alexandra Mele and Dr. Paul Despres specialize in the diagnosis and treatment of MCAS. Dr. Despres also has extensive experience evaluating for and treating CIRS, often a sequelae of uncontrolled mast cell disorders.

Because MCAS can involve virtually every organ system, symptoms are numerous. Some of the most common MCAS symptoms are:

• skin flushing, heat flushes
• urticaria or other skin rashes (especially post-exercise)
• skin itching
• multiple food sensitivities or allergies
• chemical sensitivity
• mild, moderate or severe seasonal allergies
• sneezing, post-nasal drip, cough, itchy eyes
• fainting, lightheadedness, dizziness, vertigo
• burning pains, neuropathy, neuralgia
• HA
• pain or difficulty urinating, bladder fullness
• anemia or abnormal bleeding
• fatigue, weight loss or gain, sweating
• tachycardia

Common comorbid conditions include POTS and Ehlers-Danlos Syndrome.